University of Perpetual Help System was established in 1977. Dr Antonio L Tamayo and his wife Dr Daisy M Tamayo are the founders of University of Perpetual Studies.

Dr Areta P Singson Alday was installed as the Founding Dean, a positon which she holds until now, with great distinction.

On November 7, 1997, the CHED granted autonomous status to the school, and it became the UPHR Jonelta Foundation School of Medicine with Dr Aretas P. Singhson-Alday at the helm, serving the youth of Southern Metro Manila and the Northern Calabarzon area, in their quest for medical education.